© Kamla-Raj 2004                                                                     Int J Hum Genet, 4(4): 261-264  (2004)

Chromosome Damage Induced by Ferric Chloride in

Human Peripheral Lymphocytes

Sandeep Poddar¹, Geeta Talukder¹ and  Archana Sharma²

1. Vivekananda Institute of Medical Sciences, Ramakrishna Mission Seva

Pratishthan99 Sarat Bose Road, Kolkata 700 026, West Bengal, India

2. Centre for Advanced Study in Cell and Chromosome Research, Department of

Botany, University of Calcutta, 35, Ballygunge Circular Road,

Kolkata 700 019, West Bengal, India

KEYWORDS  Ferric chloride; chromosome damage; human leucocyte culture

ABSTRACT The clastogenic activity of ferric chloride were observed on human lymphocyte culture in vitro after exposoure for 24 and 48 hrs. The results shows ferric chloride induces significantly high levels of chromosomal aberrations (%) and damaged cells (%) as compared to control. Period of exposure does not seem to affect the incidence to a significant level. Mitotic index however is reduced significantly as compared to control. The reduction being greater after exposure for 24 hours.

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