© Kamla-Raj 2002                                                                         Int J Hum Genet, 2(3): 209-211 (2002)

Detection of Dna Damage Measured by Comet Assay in Pre and Post Chemotherapeutic Acute Lymphoblastic Leukaemia

Ajanta Halder¹, Debasis Bandyopadhyay²,  Madhusnata De ¹ and  Manisha De¹

1. Genetic Toxicology Unit, Department of Genetics, Vivekananda Institute  of 

Medical  Science, Ramakrishna  Mission  Seva  Pratisthan, 99,  Sarat  Bose  Road, 

Kolkata 700  026,  West Bengal, India

2. Department of Pathology, Vivekananda Institute of Medical Science, 

Ramakrishna Mission Seva Pratisthan, 99, Sarat Bose Road, Kolkata 700 026,

West Bengal, India

Key Words Acute lymphoblastic leukemia; Comet assay; chemotherapy; single cell gel electrophoresis

Abstract  DNA damage measured by comet assay/SCGE was studied in ten cases of acute lymphoblastic leukemia before treatment and post treatment relapsed cases. The DNA damage of post treatment relapsed cases was more than untreated cases. Further study needs to be done to study DNA damage of post chemotherapy relapsed cases in both relapse and remission.

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