© Kamla-Raj 2002                                                                      Int J Hum Genet, 2(1): 65-67 (2002)

ß2-Glycoprotein I dependent anticardiolipin antibodies in women experiencing recurrent pregnancy loss

K.S.D. Kumar¹, M. Shiva Prakash²  and A. Jyothy¹

1. Institute of Genetics, Begumpet, Hyderabad, Andhra Pradesh, India

2. National Institute of Nutrition, Tarnaka, Hyderabad, Andhra Pradesh, India

Key words Anticardiolipin; autoantibodies; ß2-glycoprotein; phospholipids; predictive risk factor; recurrent pregnancy loss

ABSTRACT  Enzyme linked immunosorbent assay (ELISA) for ß2-Glycoprotein I dependent anticardiolipin antibodies (ß2I aCL) was carried out in 82 women experiencing 3 or more recurrent pregnancy losses and 82 normal healthy controls. The mean aCL levels were 14.53 (m/ml) ± 16.22 in women with repeated abortions and 7.26 (m/ml) ± 3.65 in controls. The difference in the values between the two groups was found to be highly significant (P<0.001). We suggest the usefulness of screening ß2I aCL as a routine marker in predicting the risk for future pregnancies.

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