Kamla-Raj 2003                                                                         Int J Hum Genet, 3(3): 159-163 (2003)



Ischemic Heart Disease - A Haematological, Biochemical
and Cytogenetic Study


K.A. Sajeetha Beegam, K. Sasikala, N. Meenakshi, A.L. Calistus Jude,

N. Balachandar, M. Vimala Devi and A. Asia Begum


Division of Human Genetics, Department of Zoology, Bharathiar University,

Coimbatore, Tamil Nadu, India


KEY WORDS Ischemic heart disease; chromosomal aberration; lipid profile; amino transferaces


ABSTRACT Ischemic Heart Disease (IHD) is a condition in which there is lack of oxygen to the heart due to inadequate perfusion. A study was undertaken to correlate IHD with chromosomal abnormalities. As a multifactorial disorder IHD is influenced by both environmental and genetic factors. The lipid profile in IHD was significantly altered. Deletion was a common chromosome aberration noted in the male and female subjects. In addition, aberrations such as inversion and translocation have also been noted and in the case of females 2 of them displayed a satellite chromosome and the rest showed translocation, inversion and mosaicism. The results are discussed pertaining to recent literature.


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