Kamla-Raj 2003                                                                                 Int J Hum Genet, 3(1): 1-4 (2003)



AZFc deletions in idiopathic infertile males from South India


M.  Swarna, S.  Ramesh  Babu  and  P.P. Reddy


Institute of Genetics & Hospital for Genetic Diseases, Begumpet, Hyderabad 500 016,

Andhra Pradesh, India


Key Words Infertile males; microdeletions; sequence tagged sites


Abstract  The frequency of Y chromosome microdeletions was studied on idiopathic infertile males with normal karyotype. Genomic DNA was isolated from peripheral blood and PCR analysis was carried out with STS markers SY 158 and SY 254 to detect the AZFc mutations. Out of 50 infertile males analyzed, four males exhibited AZFc deletions. The SY 158 deletions were observed in three males, viz., azoospermic, severe oligozoospermic and oligozoospermic males. In one azoospermic male SY 254 deletion was observed.


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