© Kamla-Raj 2001                                                                       Int J Hum Genet, 1(2): 109-112 (2001)

A Chromosomal Study on 100 Cases of Cerebral Palsy

Tetsuji Kadotani*, Yoko Watanabe*, Toshihide Saito**, Kunihiko Sawano**, Kazunori Minatozaki** and Tomiko Kadotani*

*The Kadotani Medical Research Foundation, 1248, Saijohigashi, Saijo,

Higashi-Hiroshima 739-0042, Japan,

Fax: +81-824-23-2289, E-mail address: kadotanila@sweet.potato.ne.jp

**Department of Pediatrics, Hiroshima Prefectural Rehabilitation Center,

295-3, Taguchi, Saijo, Higashi-Hiroshima 739-0036, Japan,

Fax: +81-824-25-1094

KEY WORDS Chromosomal aberration; cerebral palsy; congenital anomaly; fragile site

ABSTRACT  A chromosomal study was conducted on the patients of cerebral palsy with congenital anomalies. One hundred cases were investigated on the chromosomal abnormalities and fragile sites. As a result of this study, 8 cases had abnormal karyotypes showing an incidence of 8.0%. Three out of the 8 cases had chromosomal aberrations transmitted from their parents showing an incidence of 37.5%. Only one case had a folic acid sensitive heritable fragile site at 12q13. Fragile X was not detected.

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